منابع مشابه
Award Lecture
I had the pleasure of first meeting and spending two unforgettable hours with Glen Fry in 1971. I was soon to complete my undergraduate studies at Indiana University, had applied to the Indiana University optometry program, and was interested in the program at Ohio State. So I traveled to Columbus for an interview. Glenn Fry met me and personally escorted me around the facility. I had no clue a...
متن کاملEstrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture.
The concept that hormones can cause, i.e., increase the incidence of, neoplasia was first developed by Bittner et al. (1), based on experimental studies of estrogens and mammary can cer in mice. We have refined that concept into a hypothesis for a major role of estrogen and other hormones in the etiology of several human cancers (2). A key element of this hypothesis is that neoplasia is the con...
متن کاملRichard Axel - Nobel Lecture
The image in the painting La Bonne Aventure is not a nose (Fig. 1). It is a portrayal by the surrealist René Magritte of his own brain’s representation of the external world. It is a vignette that reveals a tension between image and reality, a tension that is a persistent source of creativity in art, brought to its culmination by the surrealists. The problem of how the brain represents the exte...
متن کاملToward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.
Approaches to improving the selectivity of drugs for the treatment of patients with cancer are discussed, with em phasis on folate antagonists as prototype compounds. The useof metabolites (leucovorin, 5-methyltetrahydrofolate)as “rescue' †̃ agents following methotrexate treatment with appropriate monitoring of blood levels of methotrexate has led to the safe use of this antimetabolite in hi...
متن کاملImproving the therapeutic index in breast cancer treatment: the Richard and Hinda Rosenthal Foundation Award lecture.
Improving the relationship between desired and undesired effects of therapy, the therapeutic index, is a major goal of cancer therapy. Clinical research pertinent to breast cancer treatment attempting to manipulate this therapeutic index is not restricted to studies in patients. Described herein is research in humans, mouse, machine, marrow, and molecule, concerned with either increasing care o...
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ژورنال
عنوان ژورنال: Military Medicine
سال: 1996
ISSN: 0026-4075,1930-613X
DOI: 10.1093/milmed/161.4.183